Top Laboratory Information System (LIS) companies are redefining how labs choose their partners. In 2025, labs are reevaluating LIS vendors due to new regulatory pressure, digital pathology adoption, and the shift to true SaaS models.
This guide provides a buyer-focused look at the ten most shortlisted LIS companies this year — plus practical advice on selecting the right fit for anatomic, molecular, and veterinary workflows.
How we evaluated the best Laboratory Information System vendors
When assessing the best LIS software, we focused on four signals that matter to modern labs:
- Delivery model and upgrade path
- Depth of anatomic/molecular/veterinary workflows
- Interoperability and device connectivity
- Implementation and training quality
Explore more about our top LIS vendors assessment: See our LIS Vendor Scorecard
The 2026 shortlist of top LIS companies
NovoPath
Why labs pick it: NovoPath 360 is a true SaaS LIS built for anatomic, molecular, and veterinary pathology. Customers highlight fast sign-out, flexible reporting, and strong digital pathology integrations. Our team brings best-practice playbooks so labs don’t have to invent workflows from scratch. We also equip laboratory staff with NovoU, our internal quick-reference and onboarding library, to ramp new hires quickly and keep standards consistent.
Clinisys (Sunquest, PowerPath)
Clinisys unifies several long-standing laboratory and pathology information system brands, including Sunquest and PowerPath. The company continues to support widely adopted legacy AP and LIS platforms while advancing a broader platform strategy focused on modernization. Its scale, breadth of offerings, and established presence keep Clinisys on many hospital and health system shortlists.
Epic Beaker
For Epic hospitals, Beaker remains a strong default with tight EMR integration, mature instrument interfaces, and support for point-of-care testing.
Oracle Health
Oracle Health, following its acquisition of Cerner, supports CoPathPlus as part of its broader healthcare IT portfolio. CoPathPlus remains a widely deployed anatomic pathology system within hospital and health system environments, particularly among organizations already standardized on Cerner solutions. Oracle’s focus is on integrating Cerner assets into its larger enterprise health platform, emphasizing interoperability, data infrastructure, and long-term modernization across clinical and administrative systems
Orchard Software
Orchard Software, acquired by Clinisys, serves independent, reference, and hospital-affiliated laboratories with its Orchard Enterprise and Harvest LIS platforms. Orchard is commonly used by labs scaling beyond physician office laboratory (POL) environments and offers modular support for outreach, molecular diagnostics, and anatomic pathology workflows.
CGM (LABDAQ, AP EASY, SCHUYLAB)
CompuGroup Medical’s portfolio covers reference and AP labs. LABDAQ is common in ambulatory and outreach settings; AP EASY targets anatomic pathology with cloud deployment; SCHUYLAB supports smaller labs with integrated billing options.
LigoLab
LigoLab markets an integrated Laboratory Information System plus revenue cycle management platform. Its positioning appeals to pathology groups that want laboratory operations and billing under one roof. While it remains part of the conversation, many labs evaluate it alongside more specialized LIS vendors equipped for long-term growth.
XIFIN LIS
XIFIN delivers a configurable SaaS LIS with a strong presence in AP and molecular. It is frequently positioned as an interoperable option for labs that want LIS flexibility within a broader platform.
MEDITECH Expanse (Laboratory & Pathology)
MEDITECH’s lab and pathology solutions, which offer integrated workflows and outreach modules, appeal to hospitals already running Expanse EHR.
LabVantage Medical Suite
Best known for LIMS, LabVantage also markets medical and pathology solutions. Some networks adapt it for diagnostic workflows, though the depth in AP varies.
Quick Guide: Which Vendors Align With Which Needs?
– Deep anatomic, molecular, veterinary focus: NovoPath, XIFIN, Clinisys (CoPathPlus/PowerPath)
– Hospitals optimizing around the EMR: Epic Beaker, MEDITECH Expanse, Oracle Health
– Independent and outreach labs scaling volume: NovoPath, CGM LABDAQ, Orchard
– Global enterprises and mixed domains: Clinisys portfolio, Oracle Health, LabVantage
What “Top LIS Companies 2025” Really Mean for Labs
1- True SaaS and release cadence: Cloud-hosted and true SaaS are not the same. Buyers should confirm multi-tenant architecture, standardized upgrade paths, and rollback safety. NovoPath provides a clear SaaS roadmap and consistent monthly release cadence.
2- Digital pathology readiness: Look for viewer-agnostic integrations, case synchronization, and AI-ready workflows. NovoPath is built with digital pathology at its core.
3- Interoperability and device connectivity: Evaluate native interfaces for instruments, POC devices, and EMR interoperability. NovoPath’s integrations are designed for flexibility and speed.
4- Implementation and training: Most LIS failures trace to rollout. Ask vendors about stage gates, cutover methodology, and training. NovoPath provides expert implementation, along with NovoU, to standardize adoption for AP, molecular, and veterinary teams.
FAQ
Who “has the best LIS”?
There’s no single winner for every lab. If you are AP-first, molecular-heavy, or veterinary, NovoPath is a lab information management system specifically engineered for these domains and pairs SaaS technology with proven implementation expertise. Health systems standardized on Epic or MEDITECH may prefer Beaker or Expanse for alignment with their EMR.
Is Orchard still a top option?
Yes. Orchard remains popular for laboratories moving beyond the physician office scale and needing outreach or pathology modules.
What about LIMS vendors on LIS shortlists?
Some LIMS vendors market medical suites. Labs should validate AP and molecular depth before choosing a LIMS as their LIS of record.
Why NovoPath Leads the Way
If your lab is anatomic, molecular, or veterinary and you want a modern SaaS LIS plus a proven playbook, NovoPath is built for you. With best-practice workflows, seamless integration capabilities, fast deployments, and NovoU training to scale your teams, NovoPath is positioned as the premier LIS for 2025 and beyond.
Ready to compare the best LIS vendors? See the NovoPath LIS Vendor Scorecard
